The role of cystatin C in cerebral amyloid angiopathy and stroke: Cell biology and animal models : cell biology and animal models

Summary, in English

A variant of the cysteine protease inhibitor, cystatin C, forms amyloid deposited in the cerebral vasculature of patients with hereditary cerebral hemorrhage with amyloidosis, Icelandic type (HCHWA-I), leading to cerebral hemorrhages early in life. However, cystatin C is also implicated in neuronal degenerative diseases in which it does not form the amyloid protein, such as Alzheimer disease (AD). Accumulating data suggest involvement of cystatin C in the pathogenic processes leading to amyloid deposition in cerebral vasculature and most significantly to cerebral hemorrhage in patients with cerebral amyloid angiopathy (CAA). This review focuses on cell culture and animal models used to study the role of cystatin C in these processes.

• Författare: Efrat Levy; Mariusz Jaskolski; Anders Grubb
• Avdelning/ar: Avdelningen för klinisk kemi och farmakologi
• Publiceringsår: 2006-01
• Språk: Engelska
• Sidor: 60-70
• Publikation/Tidskrift/Serie: Brain Pathology
• Volym: 16
• Issue: 1
• Länkar: http://dx.doi.org/10.1111/j.1750-3639.2006.tb00562.x
• Dokumenttyp: Artikel i tidskrift
• Förlag: Wiley-Blackwell
• Ämne: Medicinal Chemistry; Pharmacology and Toxicology
• Nyckelord: Alzheimer Disease; Animals; Cerebral Amyloid Angiopathy; Cystatin C; Cystatins; Disease Models, Animal; Humans; Neurofibrils; Stroke; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 1750-3639