Synthetic modification of salinomycin: selective O-acylation and biological evaluation
Författare
Summary, in English
Salinomycin has found renewed interest as an agent for prevention of cancer recurrence through selectively targeting cancer stem cells. Strategies for generation of improved salinomycin analogs by individual modification of its hydroxyl groups are presented. An evaluation of the dose-response effects of the resulting library on breast cancer cell lines shows that acylation of the C20 hydroxyl can be used to improve IC50 values down to one fifth that of salinomycin.
Avdelning/ar
- Centrum för analys och syntes
- Funktionell zoologi
- Bröstcancer-genetik
- NanoLund: Centre for Nanoscience
- BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
Publiceringsår
2013
Språk
Engelska
Sidor
9944-9946
Publikation/Tidskrift/Serie
Chemical Communications
Volym
49
Issue
85
Dokumenttyp
Artikel i tidskrift
Förlag
Royal Society of Chemistry
Ämne
- Chemical Sciences
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1364-548X