The Tetraspanin CD9 Affords High-Purity Capture of All Murine Hematopoietic Stem Cells
Författare
Summary, in English
Prospective isolation is critical for understanding the cellular and molecular aspects of stem cell heterogeneity. Here, we identify the cell surface antigen CD9 as a positive marker that provides a simple alternative for hematopoietic stem cell isolation at high purity. Crucially, CD9 affords the capture of all hematopoietic stem cells in murine bone marrow in the absence of contaminating populations that lack authentic stem cell function. Using CD9 as a tool to subdivide hematopoietic stem-cell-containing populations, we provide evidence for heterogeneity at the cellular, functional, and molecular levels.
Avdelning/ar
Publiceringsår
2013
Språk
Engelska
Sidor
642-648
Publikation/Tidskrift/Serie
Cell Reports
Volym
4
Issue
4
Fulltext
Dokumenttyp
Artikel i tidskrift
Förlag
Cell Press
Ämne
- Cell Biology
Status
Published
Forskningsgrupp
- Stem Cell Metabolism
ISBN/ISSN/Övrigt
- ISSN: 2211-1247