Expression of microRNAs is essential for arterial myogenic tone and pressure-induced activation of the PI3-kinase/Akt pathway.

Summary, in English

The myogenic response is the intrinsic ability of small arteries to constrict in response to increased intraluminal pressure. Although microRNAs have been shown to play a role in vascular smooth muscle function, their importance in the regulation of the myogenic response is not known. In this study, we investigate the role of microRNAs in the regulation of myogenic tone by using smooth muscle-specific and tamoxifen-inducible deletion of the endonuclease Dicer in mice.

• Författare: Anirban Bhattachariya; Diana Dahan; Karolina Turczynska; Karl Swärd; Per Hellstrand; Sebastian Albinsson
• Avdelning/ar: Kärlfysiologi; Cellulär biomekanik; Molekylär kärlfysiologi
• Publiceringsår: 2014
• Språk: Engelska
• Sidor: 288-296
• Publikation/Tidskrift/Serie: Cardiovascular Research
• Volym: 101
• Issue: 2
• Fulltext: - 1 MB; Download statistics
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/24233972?dopt=Abstract; http://dx.doi.org/10.1093/cvr/cvt253
• Dokumenttyp: Artikel i tidskrift
• Förlag: Oxford University Press
• Ämne: Cardiac and Cardiovascular Systems
• Status: Published
• Forskningsgrupp: Vascular Physiology; Cellular Biomechanics; Molecular Vascular Physiology
• ISBN/ISSN/Övrigt: ISSN: 1755-3245