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Haemophilus influenzae reside in tonsills and use IgD binding as an evasion strategy.

In English

Författare

Summary, in English

Haemophilus influenzae (Hi) causes respiratory tract infections and is also considered as a commensal, particularly in pre-school children. Tonsils from patients (n=617) undergoing tonsillectomy due to chronical infection or hypertrophy were examined. We found that 51 % of tonsils were positive for Hi, and in 95 % of cases analysed in detail (n=39) Hi resided intracellularly in the core tonsillar tissue. Patients harboured several intracellular unique strains and the majority were non-typeable Hi (NTHi). Interestingly, the isolated NTHi bound soluble immunoglobulin (Ig) D at the constant heavy chain domain 1 as revealed by recombinant IgD/IgG chimeras. NTHi also interacted with B lymphocytes via the IgD B cell receptor resulting in internalization of bacteria, T-cell independent activation via Toll like receptor 9, and differentiation into non-NTHi specific IgM producing cells. Taken together, IgD-binding NTHi leads to an unspecific immune response and may support the bacteria to circumvent the host defense.

Avdelning/ar

Publiceringsår

2014

Språk

Engelska

Sidor

1418-1428

Publikation/Tidskrift/Serie

Journal of Infectious Diseases

Volym

209

Issue

9

Dokumenttyp

Artikel i tidskrift

Förlag

Oxford University Press

Ämne

  • Infectious Medicine

Status

Published

Forskningsgrupp

  • Clinical Microbiology, Malmö
  • Clinical and Experimental Allergy Research

ISBN/ISSN/Övrigt

  • ISSN: 1537-6613