Optimizing nanovial outlet designs for improved solid-phase extraction in the integrated selective enrichment target-ISET.

Summary, in English

The integrated selective enrichment target is a microfluidic platform for SPE sample preparation with integrated nanocolumns, which simultaneously offers direct MALDI MS read-out. Here, we present a study on the importance of different nanocolumn outlet hole geometries and hole areas in relation to MS signal intensity and reproducibility. A design solution that provides the flow characteristics required for robust sample preparation using automated liquid handling is reported.

• Författare: Belinda Adler; Thomas Laurell; Simon Ekström
• Avdelning/ar: Avdelningen för Biomedicinsk teknik; MultiPark: Multidisciplinary research focused on Parkinson´s disease
• Publiceringsår: 2012
• Språk: Engelska
• Sidor: 3143-3150
• Publikation/Tidskrift/Serie: Electrophoresis
• Volym: 33
• Issue: 21
• Länkar: http://dx.doi.org/10.1002/elps.201200134
• Dokumenttyp: Artikel i tidskrift
• Förlag: John Wiley & Sons Inc.
• Ämne: Medical Engineering
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 0173-0835