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Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma

Författare:
  • S Mathas
  • M Janz
  • F Hummel
  • M Hummel
  • B Wollert-Wulf
  • S Lusatis
  • I Anagnostopoulos
  • A Lietz
  • Mikael Sigvardsson
  • F Jundt
  • K Johrens
  • K Bommert
  • H Stein
  • B Dorken
Publiceringsår: 2006
Språk: Engelska
Sidor: 207-215
Publikation/Tidskrift/Serie: Nature Immunology
Volym: 7
Nummer: 2
Dokumenttyp: Artikel
Förlag: Nature Publishing Group

Sammanfattning

B cell differentiation is controlled by a complex network of lineage-restricted transcription factors. How perturbations to this network alter B cell fate remains poorly understood. Here we show that classical Hodgkin lymphoma tumor cells, which originate from mature B cells, have lost the B cell phenotype as a result of aberrant expression of transcriptional regulators. The B cell-specific transcription factor program was disrupted by overexpression of the helix-loop-helix proteins ABF-1 and Id2. Both factors antagonized the function of the B cell-determining transcription factor E2A. As a result, expression of genes specific to B cells was lost and expression of genes not normally associated with the B lineage was upregulated. These data demonstrate the plasticity of mature human lymphoid cells and offer an explanation for the unique classical Hodgkin lymphoma phenotype.

Disputation

Nyckelord

  • Medicine and Health Sciences

Övriga

Published
Yes
  • ISSN: 1529-2908

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