Immunocytochemical demonstration of estrogen receptor beta in human periodontal ligament cells.
Författare
Summary, in English
Two transcription associated estrogen receptor (ER) subtypes have been identified and named ERα and ERβ. In the present study we investigate the expression of these ER subtypes in cultured human periodontal ligament (PDL) cells by immunocytochemistry. ERβ immunoreactivity was observed in the nuclei of about 40% of the PDL cells, while no ERα immunoreactivity was detected. In human breast cancer MCF-7 cells, serving as positive controls, both ERα and ERβ immunoreactivities were demonstrated. No immunoreactivity was observed after omission of the primary antibodies. This study suggests that estrogen acts on gene transcription preferentially via ERβ in human PDL cells.
Avdelning/ar
- Kärlfysiologi
- Neurogastroenterology
Publiceringsår
2004
Språk
Engelska
Sidor
85-88
Publikation/Tidskrift/Serie
Archives of Oral Biology
Volym
49
Issue
1
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Cell and Molecular Biology
- Gastroenterology and Hepatology
- Physiology
Nyckelord
- Periodontal ligament cells
- Estrogen receptors
- Immunocytochemistry
Status
Published
Forskningsgrupp
- Vascular Physiology
- Neurogastroenterology
ISBN/ISSN/Övrigt
- ISSN: 1879-1506