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Comparative analysis of human and bovine protein kinases reveals unique relationship and functional diversity

In English

Författare

Summary, in English

Reversible protein phosphorylation by protein kinases and phosphatases is a common event in various cellular processes. The eukaryotic protein kinase superfamily, which is one of the largest superfamilies of eukaryotic proteins, plays several roles in cell signaling and diseases. We identified 482 eukaryotic protein kinases and 39 atypical protein kinases in the bovine genome, by searching publicly accessible genetic-sequence databases. Bovines have 512 putative protein kinases, each orthologous to a human kinase. Whereas orthologous kinase pairs are, on an average, 90.6% identical, orthologous kinase catalytic domain pairs are, on an average, 95.9% identical at the amino acid level. This bioinformatic study of bovine protein kinases provides a suitable framework for further characterization of their functional and structural properties.

Publiceringsår

2011

Språk

Engelska

Sidor

587-591

Publikation/Tidskrift/Serie

Genetics and Molecular Biology

Volym

34

Issue

4

Dokumenttyp

Artikel i tidskrift

Förlag

Sociedade Brasileira de Genética

Ämne

  • Medicinal Chemistry

Nyckelord

  • aPK
  • bovine
  • ePK
  • kinome

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1678-4685