The mechanism of protein kinase C regulation
Författare
Summary, in English
Protein kinase C (PKC) is a family of serine/threonine protein kinases that plays a central role in transducing extracellular signals into a variety of intracellular responses ranging from cell proliferation to apoptosis. Nine PKC genes have been identified in the human genome, which encode 10 proteins. Each member of this protein kinase family displays distinct biochemical characteristics and is enriched in different cellular and subcellular locations. Activation of PKC has been implicated in the regulation of cell growth and differentiation. This review summarizes works of the past years in the field of PKC biochemistry that covers regulation and activation mechanism of different PKC isoforms.
Publiceringsår
2011
Språk
Engelska
Sidor
328-336
Publikation/Tidskrift/Serie
Frontiers in Biology
Volym
6
Issue
4
Fulltext
- Available as PDF - 445 kB
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Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Higher Education Press
Ämne
- Medicinal Chemistry
Nyckelord
- PKC biochemistry PKC kinase PKC phosphatases PKC structure
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1674-7984