Mapping of TLR5 and TLR7 in central and distal human airways and identification of reduced TLR expression in severe asthma.

Summary, in English

The toll-like receptors, TLR5 and TLR7, have recently been proposed in asthma immunopathogenesis. While supporting data come from animal or in vitro studies, little is known about TLR5 and TLR7 expression in human asthmatic airways.

• Författare: Medya Shikhagaie; Cecilia Andersson; Michiko Mori; I Kortekaas Krohn; Anders Bergqvist; R Dahl; Eva Ekblad; H J Hoffmann; Leif Bjermer; Jonas Erjefält
• Avdelning/ar: Luftvägsinflammation; Neurogastroenterology; Lungmedicin, allergologi och palliativ medicin; EpiHealth: Epidemiology for Health
• Publiceringsår: 2014
• Språk: Engelska
• Sidor: 184-196
• Publikation/Tidskrift/Serie: Clinical and Experimental Allergy
• Volym: 44
• Issue: 2
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/24447081?dopt=Abstract; http://dx.doi.org/10.1111/cea.12176
• Dokumenttyp: Artikel i tidskrift
• Förlag: Wiley
• Ämne: Immunology in the medical area; Respiratory Medicine and Allergy; Gastroenterology and Hepatology
• Status: Published
• Forskningsgrupp: Airway Inflammation and Immunology; Neurogastroenterology
• ISBN/ISSN/Övrigt: ISSN: 1365-2222