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Cysteinyl leukotrienes and their receptors: Bridging inflammation and colorectal cancer.

In English

Författare

Summary, in English

Long-standing inflammation has emerged as a hallmark of neoplastic transformation of epithelial cells and may be a limiting factor of successful conventional tumor therapies. A complex milieu composed of distinct stromal and immune cells, soluble factors and inflammatory mediators plays a crucial role in supporting and promoting various types of cancers. An augmented inflammatory response can predispose a patient to colorectal cancer (CRC). Common risk factors associated with CRC development include diet and lifestyle, altered intestinal microbiota and commensals, and chronic inflammatory bowel diseases. Cysteinyl leukotrienes are potent inflammatory metabolites synthesized from arachidonic acid and have a broad range of functions involved in the etiology of various pathologies. This review discusses the important role of cysteinyl leukotriene signaling in linking inflammation and CRC.

Avdelning/ar

  • Cellpatologi, Malmö
  • BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation

Publiceringsår

2014

Språk

Engelska

Sidor

968-977

Publikation/Tidskrift/Serie

World Journal of Gastroenterology

Volym

20

Issue

4

Dokumenttyp

Artikel i tidskrift

Förlag

WJG Press

Ämne

  • Gastroenterology and Hepatology

Status

Published

Forskningsgrupp

  • Cell Pathology, Malmö

ISBN/ISSN/Övrigt

  • ISSN: 1007-9327