Extensive changes in the transcriptional profile of human adipose tissue including genes involved in oxidative phosphorylation after a six months exercise intervention.

Summary, in English

Adipose tissue has an important function in total energy homeostasis and its dysregulation may contribute to life-style related diseases such as type 2 diabetes, cancer and cardiovascular diseases. The aim of this study was to investigate genome-wide mRNA expression in adipose tissue in healthy men before and after an exercise intervention to identify genes or pathways that mediate the beneficial effect of regular exercise. We also investigated the difference in adipose tissue mRNA expression between individuals with or without a family history of type 2 diabetes.

• Författare: Tina Rönn; Petr Volkov; Åsa Tornberg; Targ Elgzyri; Ola Hansson; Karl-Fredrik Eriksson; Leif Groop; Charlotte Ling
• Avdelning/ar: Translationell Muskel Forskning; Diabetes - epigenetik; Människan i rörelse: hälsa och rehabilitering; Vaskulära sjukdomar - kliniska studier; EXODIAB: Excellence of Diabetes Research in Sweden
• Publiceringsår: 2014
• Språk: Engelska
• Sidor: 188-200
• Publikation/Tidskrift/Serie: Acta Physiologica
• Volym: 211
• Issue: 1
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/24495239?dopt=Abstract; http://dx.doi.org/10.1111/apha.12247
• Dokumenttyp: Artikel i tidskrift
• Förlag: Wiley-Blackwell
• Ämne: Physiology
• Status: Published
• Projekt: Fysik aktivitet, träning och kost vid typ 2 diabetes
• Forskningsgrupp: Genomics, Diabetes and Endocrinology; Diabetes - Epigenetics; Human Movement: health and rehabilitation; Vascular Diseases - Clinical Research
• ISBN/ISSN/Övrigt: ISSN: 1748-1716