A Comparative Analysis of the Mechanism of Toll-Like Receptor-Disruption by TIR-Containing Protein C from Uropathogenic Escherichia coli.

Summary, in English

The TIR-containing protein C (TcpC) of uropathogenic Escherichia coli strains is a powerful virulence factor by impairing the signaling cascade of Toll-like receptors (TLRs). Several other bacterial pathogens like Salmonella, Yersinia, Staphylococcus aureus but also non-pathogens express similar proteins. We discuss here the pathogenic potential of TcpC and its interaction with TLRs and TLR-adapter proteins on the molecular level and compare its activity with the activity of other bacterial TIR-containing proteins. Finally, we analyze and compare the structure of bacterial TIR-domains with the TIR-domains of TLRs and TLR-adapters.

• Författare: Anna Waldhuber; Greg A Snyder; Franziska Römmler; Christine Cirl; Tina Müller; Tsan Sam Xiao; Catharina Svanborg; Thomas Miethke
• Avdelning/ar: Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG
• Publiceringsår: 2016
• Språk: Engelska
• Sidor: 1-8
• Publikation/Tidskrift/Serie: Pathogens
• Volym: 5
• Issue: 25
• Fulltext: - 711 kB; Download statistics
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/26938564?dopt=Abstract; http://dx.doi.org/10.3390/pathogens5010025
• Dokumenttyp: Artikel i tidskrift
• Förlag: MDPI AG
• Ämne: Microbiology in the medical area
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 2076-0817