microRNA-125 distinguishes developmentally generated and adult-born olfactory bulb interneurons.
Författare
Summary, in English
New neurons, originating from the subventricular zone, are continuously integrating into neuronal circuitry in the olfactory bulb (OB). Using a transgenic sensor mouse, we found that adult-born OB interneurons express microRNA-125 (miR-125), whereas the pre-existing developmentally generated OB interneurons represent a unique population of cells in the adult brain, without miR-125 activity. Stable inhibition of miR-125 in newborn OB neurons resulted in enhanced dendritic morphogenesis, as well as in increased synaptic activation in response to odour sensory stimuli. These data demonstrate that miR-125 controls functional synaptic integration of adult-born OB interneurons. Our results also suggest that absence of an otherwise broadly expressed miRNA is a novel mechanism with which to achieve neuronal subtype specification.
Avdelning/ar
Publiceringsår
2014
Språk
Engelska
Sidor
1580-1588
Publikation/Tidskrift/Serie
Development: For advances in developmental biology and stem cells
Volym
141
Issue
7
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
The Company of Biologists Ltd
Ämne
- Developmental Biology
Status
Published
Forskningsgrupp
- Molecular Neurogenetics
- Neurobiology
ISBN/ISSN/Övrigt
- ISSN: 1477-9129