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Identification of Missing Proteins – Towards the Completion of Human Proteome

In English

Författare

  • Ákos Végvári

Redaktör

  • György Marko-Varga

Summary, in English

As the Human Proteome Project has outlined currently many research groups worldwide dedicated resources to focus on the completion of the human proteome catalogue. According to the project directives, not only all products of ca. 20,300 protein coding genes should be identified but also at least one splicing variant, one single nucleotide polymorphism product and some major post-translational modifications of all human proteins. Today, about 22% of the human proteins have never been observed at expression level but most cases their coding genes were found active and transcript level of identification was achieved.

This chapter presents the recent state of the Human Proteome Project and the challenges that the completion of the human protein catalogue represents. Furthermore, discuss the most useful techniques, such as mass spectrometric technologies employed together with bioinformatic tools for identification of novel proteoforms. Databases and their functions are reviewed as well as a successful detection of mutant proteins is exemplified.

Publiceringsår

2014

Språk

Engelska

Sidor

7-18

Publikation/Tidskrift/Serie

Genomics and Proteomics for Clinical Discovery and Development

Dokumenttyp

Del av eller Kapitel i bok

Förlag

Springer

Ämne

  • Medical Engineering

Nyckelord

  • Human Proteome Project
  • mass spectrometry
  • selected reaction monitoring
  • prostate specific antigen

Status

Published

ISBN/ISSN/Övrigt

  • ISBN: 978-94-017-9201-1