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Brain pericytes acquire a microglial phenotype after stroke.

In English

Författare

Summary, in English

Pericytes are located on the abluminal side of endothelial cells lining the microvasculature in all organs. They have been identified as multipotent progenitor cells in several tissues of the body including the human brain. New evidence suggests that pericytes contribute to tissue repair, but their role in the injured brain is largely unknown. Here, we investigate the role of pericytes in ischemic stroke. Using a pericyte-reporter mouse model, we provide unique evidence that regulator of G-protein signaling 5 expressing cells are activated pericytes that leave the blood vessel wall, proliferate and give rise to microglial cells after ischemic brain injury. Consistently, we show that activated pericytes express microglial markers in human stroke brain tissue. We demonstrate that human brain-derived pericytes adopt a microglial phenotype and upregulate mRNA specific for activated microglial cells under hypoxic conditions in vitro. Our study indicates that the vasculature is a novel source of inflammatory cells with a microglial phenotype in brain ischemia and hence identifies pericytes as an important new target for the development of future stroke therapies.

Publiceringsår

2014

Språk

Engelska

Sidor

381-396

Publikation/Tidskrift/Serie

Acta Neuropathologica

Volym

128

Issue

3

Dokumenttyp

Artikel i tidskrift

Förlag

Springer

Ämne

  • Neurosciences

Status

Published

Forskningsgrupp

  • Neuroinflammation
  • Stem Cell Metabolism

ISBN/ISSN/Övrigt

  • ISSN: 1432-0533