Infiltration of CD3(+) and CD68(+) cells in bladder cancer is subtype specific and affects the outcome of patients with muscle-invasive tumors.
Författare
Summary, in English
Urothelial carcinoma (UC) aggressiveness is determined by tumor inherent molecular characteristics, such as molecular subtypes, as well as by host reactions directed toward the tumor. Cell types responsible for the host׳s response include tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs). The aim of the present investigation was to explore the immunological response in relation to UC molecular subtypes and to evaluate the prognostic effect of TIL and TAM counts in tissue sections from muscle-invasive (MI) tumors.
Avdelning/ar
- Genomiska analyser av urinblåscancer
- Urological research, Malmö
- Bröstcancer-genetik
- Urologi
- BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
- Cancerimmunologi, Malmö
- Avdelningen för translationell cancerforskning
Publiceringsår
2014
Språk
Engelska
Sidor
791-797
Publikation/Tidskrift/Serie
Urologic Oncology
Volym
32
Issue
6
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Urology and Nephrology
- Cancer and Oncology
Status
Published
Forskningsgrupp
- Urothelial Cancer Genomics
- Urological research, Malmö
- Urology
- Cancer Immunology, Malmö
ISBN/ISSN/Övrigt
- ISSN: 1873-2496