Webbläsaren som du använder stöds inte av denna webbplats. Alla versioner av Internet Explorer stöds inte längre, av oss eller Microsoft (läs mer här: * https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Var god och använd en modern webbläsare för att ta del av denna webbplats, som t.ex. nyaste versioner av Edge, Chrome, Firefox eller Safari osv.

Increased Heterogeneity of Bone Matrix Mineralization in Pediatric Patients Prone to Fractures: A Biopsy Study

In English

Författare

  • Inari S. Tamminen
  • Barbara M. Misof
  • Paul Roschger
  • Mervi K. Mayranpaa
  • Mikael J. Turunen
  • Hanna Isaksson
  • Heikki Kroger
  • Outi Makitie
  • Klaus Klaushofer

Summary, in English

Idiopathic osteoporosis (IOP) in children is characterized by fragility fractures and/or low bone mineral density in otherwise healthy individuals. The aim of the present work was to measure bone mineralization density distribution (BMDD) based on quantitative backscattered electron imaging (qBEI) in children with suspected IOP. Entire cross-sectional areas of transiliac bone biopsy samples from children (n=24, 17 boys; aged 6.7-16.6 years) with a history of fractures (n=14 with at least one vertebral fracture) were analyzed for cancellous (Cn) and cortical (Ct) BMDD. Outcomes were compared with normal reference BMDD data and correlated with the patients' clinical characteristics and bone histomorphometry findings. The subjects had similar average degree but significantly higher heterogeneity of mineralization in both Cn and Ct bone (Cn.CaWidth +23%, Ct.CaWidth +15%, p<0.001 and p=0.002, respectively), together with higher percentages of low mineralized cancellous (Cn.CaLow +35%, p<0.001) and highly mineralized cortical bone areas (Ct.CaHigh +82%, p=0.032). Ct.CaWidth and Ct.CaLow were positively correlated with mineralizing surface per bone surface (MS/BS; a primary histomorphometric determinant of bone formation) and with serum bone turnover markers (all p<0.05). The correlations of the mineralization heterogeneity with histomorphometric and serum bone turnover indices suggest that an enhanced variation in bone turnover/formation contributes to the increased heterogeneity of mineralization. However, it remains unclear whether the latter is cause for, or the response to the increased bone fragility in these children with suspected IOP. (c) 2014 American Society for Bone and Mineral Research.

Avdelning/ar

Publiceringsår

2014

Språk

Engelska

Sidor

1110-1117

Publikation/Tidskrift/Serie

Journal of Bone and Mineral Research

Volym

29

Issue

5

Dokumenttyp

Artikel i tidskrift

Förlag

Wiley-Blackwell

Ämne

  • Mechanical Engineering

Nyckelord

  • QUANTITATIVE BACKSCATTERED ELECTRON IMAGING
  • QBEI
  • BONE MINERALIZATION
  • DENSITY DISTRIBUTION
  • BMDD
  • IDIOPATHIC OSTEOPOROSIS
  • CHILDREN
  • HISTOMORPHOMETRY
  • VERTEBRAL FRACTURE

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1523-4681