Cardiovascular consequences of a polygenetic component of blood pressure in an urban-based longitudinal study: the Malmö Diet and Cancer.

Summary, in English

A recently published genome wide association study identified 29 single nucleotide polymorphisms (SNPs) influencing blood pressure (BP). Case-control studies suggest that a genetic risk score (GRS) based on these 29 SNPs affect the risk of cardiovascular disease (CVD), but its role for CVD at population level is unknown. Here, we prospectively evaluate the impact of this polygenetic BP component on CVD morbidity and mortality in a large urban-based middle-aged population.

• Författare: Cristiano Fava; Therese Ohlsson; Marketa Sjögren; Angela Tagetti; Peter Almgren; Gunnar Engström; Peter Nilsson; Bo Hedblad; Pietro Minuz; Olle Melander
• Avdelning/ar: Translationell Muskel Forskning; Kardiovaskulär forskning - hypertoni; Kardiovaskulär forskning - epidemiologi; Internmedicin - epidemiologi; EXODIAB: Excellence of Diabetes Research in Sweden; EpiHealth: Epidemiology for Health
• Publiceringsår: 2014
• Språk: Engelska
• Sidor: 1424-1428
• Publikation/Tidskrift/Serie: Journal of Hypertension
• Volym: 32
• Issue: 7
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/24879493?dopt=Abstract; http://dx.doi.org/10.1097/HJH.0000000000000209
• Dokumenttyp: Artikel i tidskrift
• Förlag: Lippincott Williams & Wilkins
• Ämne: Cardiac and Cardiovascular Systems
• Status: Published
• Projekt: Genetic causes and prediction of hypertension
• Forskningsgrupp: Genomics, Diabetes and Endocrinology; Cardiovascular Research - Hypertension; Cardiovascular Research - Epidemiology; Internal Medicine - Epidemiology
• ISBN/ISSN/Övrigt: ISSN: 1473-5598