Pediatric solid organ transplantation and osteoporosis: a descriptive study on bone histomorphometric findings
Författare
Summary, in English
Organ transplantation may lead to secondary osteoporosis in children. This study characterized bone histomorphometric findings in pediatric solid organ transplant recipients who were assessed for suspected secondary osteoporosis. Iliac crest biopsies were obtained from 19 children (7.6-18.8 years, 11 male) who had undergone kidney (n = 6), liver (n = 9), or heart (n = 4) transplantation a median 4.6 years (range 0.6-16.3 years) earlier. All patients had received oral glucocorticoids at the time of the biopsy. Of the 19 patients, 21 % had sustained peripheral fractures and 58 % vertebral compression fractures. Nine children (47 %) had a lumbar spine BMD Z-score below -2.0. Histomorphometric analyses showed low trabecular bone volume (< -1.0 SD) in 6 children (32 %) and decreased trabecular thickness in 14 children (74 %). Seven children (37 %) had high bone turnover at biopsy, and low turnover was found in 6 children (32 %), 1 of whom had adynamic bone disease. There was a great heterogeneity in the histological findings in different transplant groups, and the results were unpredictable using non-invasive methods. The observed changes in bone quality (i.e. abnormal turnover rate, thin trabeculae) rather than the actual loss of trabecular bone, might explain the increased fracture risk in pediatric solid organ transplant recipients.
Avdelning/ar
Publiceringsår
2014
Språk
Engelska
Sidor
1431-1440
Publikation/Tidskrift/Serie
Pediatric Nephrology
Volym
29
Issue
8
Dokumenttyp
Artikel i tidskrift
Förlag
Springer
Ämne
- Orthopedics
Nyckelord
- Bone histomorphometry
- Cancellous bone
- Organ transplantation
- Fracture
- Glucocorticoid treatment
- Children
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1432-198X