The global distribution and evolution of deoxyribonucleoside kinases in bacteria
Författare
Summary, in English
Deoxyribonucleoside kinases (dNKs) are important to DNA metabolism, especially in environments where nucleosides are freely available to be absorbed and used for the salvage pathway. Little has previously been known about the complement of dNKs in different bacterial genomes. However, it was believed that Gram-negative bacteria had a single dNK, while Gram-positive bacteria possessed several. An analysis of 992 fully sequenced bacterial genomes, including both Gram-positive and Gram-negative organisms, was conducted to investigate the phylogenetic relationship of all TK1-like and non-TK1-like dNKs. It was illustrated that both gene families evolved through a number of duplications and horizontal gene transfers, leading to the presence of multiple dNKs in different types of bacteria. The findings of this study provide a backbone for further studies into the evolution of the interplay between the de novo and salvage pathways in DNA synthesis with respect to environmental availability of deoxyribonucleosides and metabolic processes generating the provisions of different dNTPs. (C) 2011 Elsevier B.V. All rights reserved.
Avdelning/ar
Publiceringsår
2012
Språk
Engelska
Sidor
117-120
Publikation/Tidskrift/Serie
Gene
Volym
492
Issue
1
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Biological Sciences
Nyckelord
- Deoxyribonucleoside kinase
- Evolution
- Phylogeny
- Salvage pathway
- Gene
- duplication
- Horizontal transfer
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1879-0038