SOCS6 is a selective suppressor of receptor tyrosine kinase signaling
Författare
Summary, in English
The suppressors of cytokine signaling (SOCS) are well-known negative regulators of cytokine receptor signaling. SOCS6 is one of eight members of the SOCS family of proteins. Similar to other SOCS proteins, SOCS6 consists of an uncharacterized extended N-terminal region followed by an SH2 domain and a SOCS box. Unlike other SOCS proteins, SOCS6 is mainly involved in negative regulation of receptor tyrosine kinase signaling. SOCS6 is widely expressed in many tissues and is found to be downregulated in many cancers including colorectal cancer, gastric cancer, lung cancer, ovarian cancer, stomach cancer, thyroid cancer, hepatocellular carcinoma, and pancreatic cancer. SOCS6 is involved in negative regulation of receptor signaling by increasing degradation mediated by ubiquitination of receptors or substrate proteins and induces apoptosis by targeting mitochondrial proteins. Therefore, SOCS6 turns out as an important regulator of survival signaling and its activity is required for controlling receptor tyrosine kinase signaling.
Avdelning/ar
- Avdelningen för translationell cancerforskning
- BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
Publiceringsår
2014
Språk
Engelska
Sidor
10581-10589
Publikation/Tidskrift/Serie
Tumor Biology
Volym
35
Issue
11
Fulltext
Dokumenttyp
Artikel i tidskrift
Förlag
Springer
Ämne
- Cancer and Oncology
Nyckelord
- SOCS
- FLT3
- KIT
- INSR
- SCF
- Insulin
- FL
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1423-0380