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Evolutionary relations between subtypes of telomere-associated repeats in Chironomus

Författare

Summary, in English

Telomere-associated DNA in Chironomus pallidivittatus contains tandemly repeated 340-bp units. We show that they are distributed among several subtypes of which we have characterized two, M1 and D1, with regard to base sequence, homogeneity, and intertelomeric distribution. Each subpopulation is highly homogeneous and the two subtypes have identical consensus sequences throughout 90% of their lengths. In the remaining part the homology is only about 60%. Each subpopulation has its specific intertelomeric distribution and there is no difference in the degree of homogenization within and between telomeres. The repeat unit contains two pairs of subrepeats embedded in linker DNA. This provides a model that makes it possible to relate the two subtypes to each other with regard to evolutionary history. The difference between the two subtypes is due to mutations that have occurred in only one of them, D1, resulting in a decreased similarity between one of its pairs of subrepeats. This type of repeat unit is therefore believed to be derived from the other, M1. The local decrease in similarity between M1 and D1 suggests that homogenization between them occurs by gene conversion.

Publiceringsår

1991

Språk

Engelska

Sidor

463-468

Publikation/Tidskrift/Serie

Journal of Molecular Evolution

Volym

32

Issue

6

Dokumenttyp

Artikel i tidskrift

Förlag

Springer

Ämne

  • Genetics

Status

Published

Forskningsgrupp

  • Molecular Genetics and Genetics

ISBN/ISSN/Övrigt

  • ISSN: 0022-2844