High Plasma Levels of Heparin-Binding Epidermal Growth Factor Are Associated With a More Stable Plaque Phenotype and Reduced Incidence of Coronary Events.
Författare
Summary, in English
Rupture of atherosclerotic plaques is the major cause of acute coronary events (CEs). Plaque destabilization is the consequence of an imbalance between inflammatory-driven degradation of fibrous tissue and smooth muscle cell-dependent tissue repair. Proinflammatory factors have been documented extensively as biomarkers of cardiovascular risk but factors that contribute to stabilization of atherosclerotic plaques have received less attention. The present study aimed to investigate whether plasma levels of the smooth muscle cell growth factor epidermal growth factor (EGF), heparin-binding-EGF (HB-EGF), and platelet-derived growth factor correlate with plaque phenotype and incidence of CEs.
Avdelning/ar
Publiceringsår
2015
Språk
Engelska
Sidor
222-228
Publikation/Tidskrift/Serie
Arteriosclerosis, Thrombosis and Vascular Biology
Volym
35
Issue
1
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Lippincott Williams & Wilkins
Ämne
- Cardiac and Cardiovascular Systems
Status
Published
Forskningsgrupp
- Cardiovascular Research - Immunity and Atherosclerosis
- Cardiovascular Research - Epidemiology
- Cardiovascular Research - Translational Studies
ISBN/ISSN/Övrigt
- ISSN: 1524-4636