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Effects of Physical Exercise on Neuroinflammation, Neuroplasticity, Neurodegeneration, and Behavior: What We Can Learn From Animal Models in Clinical Settings.

Författare

Summary, in English

Physical exercise is a cornerstone in the management of many neurodegenerative disorders, such as Parkinson's disease, dementia, and stroke. However, much of its beneficial effects on improving motor functions and cognition as well as decreasing neurodegeneration and neuroinflammation are not yet well understood. The obvious limitations of studying the protective mechanisms behind exercise, for example, brain plasticity and neurodegeneration, could be overcome by generating novel animal models of neurodegenerative disorders. In this narrative review, we discuss the beneficial effects of exercise performed in animal models of neurodegenerative disorders and how the results from animal studies can be used in clinical settings. From preclinical studies, the positive effects of exercise have been related to increased levels of neurotrophic factors, elevated expression of anti-inflammatory cytokines, and reduced levels of pro-inflammatory cytokines and activated microglia. It is clear that parameters influencing the effect of exercise, such as intensity, still remain to be investigated in animal studies in order to find the optimal program that can be translated into exercise interventions for patients with neurodegenerative diseases.

Publiceringsår

2015

Språk

Engelska

Sidor

577-589

Publikation/Tidskrift/Serie

Neurorehabilitation and Neural Repair

Volym

29

Issue

6

Dokumenttyp

Artikel i tidskrift

Förlag

SAGE Publications

Ämne

  • Other Medical Sciences not elsewhere specified
  • Neurosciences

Status

Published

Forskningsgrupp

  • Neuroinflammation
  • Rehabilitation medicine

ISBN/ISSN/Övrigt

  • ISSN: 1552-6844