Absence of Epstein-Barr and Cytomegalovirus Infection in Neuroblastoma Cells by Standard Detection Methodologies.
Författare
Summary, in English
Indications exist in the scientific literature that infection with human herpes family viruses may contribute to the pathogenesis of neuroblastoma (NB). However, systematic investigations regarding viral presence in NB cells have been scarcely reported. Here, the presence of DNA from Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) was assessed by PCR in 12 NBs, supplemented with RNA in situ hybridization, immunohistochemical detection, and high-throughput DNA sequencing. These standard methods did not detect infection by EBV or HCMV in NB cells in any tumor, while occasional immune cells were positive for EBV RNA or HCMV protein in four cases. Pediatr Blood Cancer © 2013 Wiley Periodicals, Inc.
Avdelning/ar
- Avdelningen för klinisk genetik
- Klinisk mikrobiologi, Malmö
- Neurokirurgi
- Internmedicin - epidemiologi
- Pediatrik, Lund
- EpiHealth: Epidemiology for Health
- BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
Publiceringsår
2013
Språk
Engelska
Sidor
91-93
Publikation/Tidskrift/Serie
Pediatric Blood & Cancer
Volym
60
Issue
9
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
John Wiley & Sons Inc.
Ämne
- Pediatrics
Status
Published
Forskningsgrupp
- Clinical Microbiology, Malmö
- Internal Medicine - Epidemiology
ISBN/ISSN/Övrigt
- ISSN: 1545-5017