Pitfalls in the interpretation of long-term inhalation experiments
Författare
Summary, in English
Age- and weight-matched groups of mice were enclosed in airtight chambers and exposed to clean, filtered air for 1 month. At the end of the exposure period, body, liver and spleen weights and plasma butyrylcholinesterase (BuChE) activity were measured. More than twice as many significant differences in these parameters occurred compared with the expected results if only random differences existed between the groups. Thus, isolation of animal groups for extended periods of time in inhalation experiments alone may lead to differences in various biological parameters. When testing the effects of unknown substances such differences may be mistaken for reactions to the test agent, which actually may have no effect.
Avdelning/ar
Publiceringsår
1984
Språk
Engelska
Sidor
213-218
Publikation/Tidskrift/Serie
Toxicology Letters
Volym
21
Issue
2
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Pharmacology and Toxicology
Nyckelord
- Body weight
- exposure
- inhalation
- kidney
- liver
- mouse
- spleen
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1879-3169