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Hunting for Protein Markers of Hypoxia by Combining Plasma Membrane Enrichment with a New Approach to Membrane Protein Analysis

Författare

Summary, in English

Nontransient hypoxia is strongly associated with malignant lesions, resulting in aggressive behavior and resistance to treatment. We present an analysis of mRNA and protein expression changes in neuroblastoma cell lines occurring upon the transition from normoxia to hypoxia. The correlation between mRNA and protein level changes was poor, although some known hypoxia-driven genes and proteins correlated well. We present previously undescribed membrane proteins expressed under hypoxic conditions that are candidates for evaluation as biomarkers.

Publiceringsår

2011

Språk

Engelska

Sidor

1645-1656

Publikation/Tidskrift/Serie

Journal of Proteome Research

Volym

10

Issue

4

Dokumenttyp

Artikel i tidskrift

Förlag

The American Chemical Society (ACS)

Ämne

  • Biophysics
  • Immunology in the medical area

Nyckelord

  • isotopic labeling
  • HPLC-MS
  • 2D-PAGE
  • plasma membrane
  • protein
  • expression
  • mRNA expression
  • correlation
  • hypoxia
  • normoxia
  • neuroblastoma

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1535-3893