Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
Författare
Summary, in English
New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight into disease etiology. We analyzed 386,731 common single-nucleotide polymorphisms (SNPs) in 1464 patients with T2D and 1467 matched controls, each characterized for measures of glucose metabolism, lipids, obesity, and blood pressure. With collaborators (FUSION and WTCCC/UKT2D), we identified and confirmed three loci associated with T2D - in a noncoding region near CDKN2A and CDKN2B, in an intron of IGF2BP2, and an intron of CDKAL1 - and replicated associations near HHEX and in SLC30A8 found by a recent whole-genome association study. We identified and confirmed association of a SNP in an intron of glucokinase regulatory protein (GCKR) with serum triglycerides. The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues to the pathogenesis of common diseases.
Avdelning/ar
Publiceringsår
2007
Språk
Engelska
Sidor
1331-1336
Publikation/Tidskrift/Serie
Science
Volym
316
Issue
5829
Dokumenttyp
Artikel i tidskrift
Förlag
American Association for the Advancement of Science (AAAS)
Ämne
- Other Clinical Medicine
- Public Health, Global Health, Social Medicine and Epidemiology
- Medicinal Chemistry
- Endocrinology and Diabetes
Status
Published
Forskningsgrupp
- Translational Muscle Research
- Community Medicine
- Cardiovascular Research - Hypertension
- Internal Medicine - Epidemiology
- Clinical Chemistry, Malmö
ISBN/ISSN/Övrigt
- ISSN: 1095-9203