Prognostic implications of cytogenetic aberrations in diffuse large B-cell lymphomas
Författare
Summary, in English
A single institution series of 81 consecutive, cytogenetically analyzed, diffuse large B-cell lymphomas (DLBL), the majority of which treated with anthracycline-containing combination chemotherapy, were reviewed retrospectively to investigate whether the karyotypic pattern or certain abnormalities correlate with survival. Clonal chromosome changes were found in 79 of the 81 cases. The prognostic impact of the following aberrations, all suggested in previous studies to be associated with either shorter or longer survival, were tested: 1q21-23 breakpoints, +2/dup(2p), +3/dup(3p), +5, +6, 6q21-25 breakpoints, monosomy 7/der(7p)/i(7q), trisomy 7, 14q11-12 breakpoints, monosomy 17/der(17p)/i(17q), trisomy 18, > 4 marker chromosomes, > 4 breakpoints, and > or = 10 abnormalities. Univariate analysis showed that a breakpoint at 1q21-23 or trisomy 6 was associated with a shorter survival. However, when adjusted for age, stage, performance status and lactate dehydrogenase level, none of the cytogenetic aberrations had an independent prognostic value. Thus, the present investigation provides no support for any of the above-mentioned abnormalities being of prognostic importance in DLBL.
Publiceringsår
1999
Språk
Engelska
Sidor
184-190
Publikation/Tidskrift/Serie
European Journal of Haematology
Volym
62
Issue
3
Dokumenttyp
Artikel i tidskrift
Förlag
Wiley-Blackwell
Ämne
- Hematology
Nyckelord
- B-Lymphocyte
- Large cell lymphoma
- Chromosomal aberration
- Cytogenetics
- Prognosis
- Human
- Non Hodgkin lymphoma
- Lymphoproliferative syndrome
- Malignant hemopathy
- Genetics
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1600-0609