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Fibre type composition of rabbit tibialis anterior and extensor digitorum longus muscles

In English

Författare

  • Jan Lexell
  • J C Jarvis
  • J Currie
  • D Y Downham
  • S Salmons

Summary, in English

Rabbit tibialis anterior (TA) and extensor digitorum longus (EDL) muscles are used extensively in studies of stimulation-induced fibre type transformation, but the proportions and sizes of the 2 main fibre types, and the way in which they are distributed within the muscles, have never been described in any detail. In this study, transverse sections were processed by enzyme histochemical and immunohistochemical techniques and assessed morphometrically. The data were analysed by multivariate methods. In both TA and EDL muscles, the proportion of type 1 fibres varied significantly, and to a similar extent, within a cross-section, from lateral to medial and from superficial to deep parts. The fibre density, an indirect estimate of the mean muscle fibre area, also varied significantly, but not systematically, within a cross-section. For the EDL muscle, the proportion of type 1 fibres was consistently higher in the distal than in the proximal part of the muscle. The proportion of type 1 fibres was also significantly higher in the EDL than in the TA muscle for each of the 6 rabbits. There was no systematic variation between muscles from left and right limbs. The type proportions and fibre densities for both TA and EDL muscles differed significantly between individual rabbits, but not between sexes. The study provides a database that has hitherto been lacking on normal fibre type composition and its variation within and between these experimentally important muscles.

Avdelning/ar

Publiceringsår

1994

Språk

Engelska

Sidor

95-101

Publikation/Tidskrift/Serie

Journal of Anatomy

Volym

185

Issue

Pt 1

Dokumenttyp

Artikel i tidskrift

Förlag

John Wiley & Sons Inc.

Ämne

  • Surgery
  • Neurology

Nyckelord

  • Muscle histochemistry
  • immunocytochemistry

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 0021-8782