Cyclin A1 regulates the interactions between mouse hematopoietic stem and progenitor cells and their niches.
Författare
Summary, in English
It remains poorly understood how the hematopoietic stem/progenitor cells (HSPC) are attracted to their niches and the functional consequences of such interaction. In the present study, we show that the cell cycle regulator cyclin A1 in association with vascular endothelial growth factor receptor 1 (VEGFR1), is required for HSPC and their niches to maintain their function and proper interaction. In the absence of cyclin A1, the HSPC in the BM are increased in their frequency and display an increased migratory and homing ability. Concomitantly, the ability of the endosteal and central BM niche zones to attract and home the wild-type HSPC is significantly reduced in cyclin A1-null mice as compared to the wild-type controls. The impaired proliferation and homing of HSPC in the BM of cyclin A1-null mice are attributed to the increased density of microvessels in the endosteal and central BM niche zones, which is associated with the increased VEGFR1 expression. Thus, modulation of cyclin A1 and VEGFR1 in HSPC and their niches may provide new insights into therapeutic approaches.
Avdelning/ar
- Experimentell cancerforskning, Malmö
- Cellpatologi, Malmö
- BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
- Institutionen för translationell medicin
Publiceringsår
2015
Språk
Engelska
Sidor
1948-1960
Publikation/Tidskrift/Serie
Cell Cycle
Volym
14
Issue
12
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Landes Bioscience
Ämne
- Cell Biology
Status
Published
Forskningsgrupp
- Experimental Cancer Research, Malmö
- Cell Pathology, Malmö
ISBN/ISSN/Övrigt
- ISSN: 1551-4005