SOCS6 (suppressor of cytokine signaling 6)
Författare
Summary, in English
The suppressor of cytokine signaling (SOCS) family of proteins are well known negative regulators of cytokine receptors signaling consisting of eight structurally similar proteins, SOCS1-7 and CIS. A key feature of this family of proteins is the presence of two structural motifs: a centrally located SH2 domain and a SOCS box in the C-terminus. The SOCS box mediates the interaction with the Elongins B and C complex while an additional motif mediates its interaction with Cullin 5 to assemble a Cullin/Ring ubiquitin ligase. In this complex SOCS6 acts as a substrate recognition subunit through interactions mediated by the N-terminus and the SH2 domain. SOCS6 interacts with tyrosine kinase receptors FLT3 and c-KIT and modulate their ubiquitination and function.
Avdelning/ar
- Avdelningen för translationell cancerforskning
- BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
Publiceringsår
2015
Språk
Engelska
Sidor
50-52
Publikation/Tidskrift/Serie
Atlas of Genetics and Cytogenetics in Oncology and Haematology
Volym
19
Issue
1
Dokumenttyp
Artikel i tidskrift
Förlag
ARMGHM / NIST - CNRS
Ämne
- Cancer and Oncology
Nyckelord
- CIS4
- SSI4
- CIS-4
- SOCS4
- STAI4
- SOCS-4
- SOCS-6
- STATI4
- HSPC060.
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1768-3262