IL-17A is Elevated in End-stage COPD and Contributes to Cigarette Smoke-induced Lymphoid Neogenesis.

Summary, in English

End-stage chronic obstructive pulmonary disease (COPD) is associated with an accumulation of pulmonary lymphoid follicles. Interleukin (IL)-17A is implicated in COPD and pulmonary lymphoid neogenesis in response to microbial stimuli. We hypothesized that IL-17A is increased in peripheral lung tissue during end-stage COPD and also directly contributes to cigarette smoke-induced lymphoid neogenesis.

• Författare: Abraham Roos; Caroline Sandén; Michiko Mori; Leif Bjermer; Martin R Stampfli; Jonas Erjefält
• Avdelning/ar: Luftvägsinflammation; Lungmedicin, allergologi och palliativ medicin; EpiHealth: Epidemiology for Health
• Publiceringsår: 2015
• Språk: Engelska
• Sidor: 1232-1241
• Publikation/Tidskrift/Serie: American Journal of Respiratory and Critical Care Medicine
• Volym: 191
• Issue: 11
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/25844618?dopt=Abstract; http://dx.doi.org/10.1164/rccm.201410-1861OC
• Dokumenttyp: Artikel i tidskrift
• Förlag: American Thoracic Society
• Ämne: Respiratory Medicine and Allergy
• Status: Published
• Forskningsgrupp: Airway Inflammation and Immunology
• ISBN/ISSN/Övrigt: ISSN: 1535-4970