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An improved probing controller for substrate feeding in fed-batch culteres of E. coli: simulations and experiments

Publiceringsår: 2002
Språk: Engelska
Sidor: 213-218
Publikation/Tidskrift/Serie: Computer Applications in Biotechnology 2001
Dokumenttyp: Konferensbidrag
Förlag: Pergamon-Elsevier Science


A strategy for feedback control of the glucose feed rate in cultivations of E.coli is discussed. By making probing pulses in the feedrate it is possible to detect and avoid undesirable by-productformation using a standard dissolved oxygen sensor. The feasibility of an improved and simplified probing algorithm is demonstrated by simulations as well as laboratory-scale experiments.



  • Technology and Engineering
  • Fermentation process
  • probing
  • extremum control
  • process control


8th IFAC International Conference on Computer Applications in Biotechnology (CAB8)
Quebeq City, Canada
  • ISBN: 0080436811

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