Intakes of omega-3 polyunsaturated fatty acids and blood pressure change over time: Possible interaction with genes involved in 20-HETE and EETs metabolism.

Summary, in English

A high intake of omega-3 polyunsaturated fatty acids (ω-3 PUFAs), has been associated with reduced levels of blood pressure (BP). Their antihypertensive action may be due to the reduction of the ω-6/ω-3 ratio and the resulting competitive effect of ω-3 as compared to arachidonic acid (an ω-6 PUFA) as a substrate of cytochrome P450 (CYP450) enzymes involved in the production of vasoactive mediators. Some functional polymorphisms (SNPs), in genes which encode for the same enzymes, were associated with hypertension and ischemic stroke in the Malmö Diet and Cancer (MDC), a Swedish urban-based longitudinal study. The aim of this study was to evaluate the effect of the intake of different types of PUFAs on BP change over time (Δ-BP; mean follow-up 16.6±1.5 years; n=3.550 with complete phenotypic data), also considering the interaction with SNPs in genes involved in their metabolism via CYP450.

• Författare: Angela Tagetti; Ulrika Ericson; Martina Montagnana; Elisa Danese; Peter Almgren; Peter Nilsson; Gunnar Engström; Bo Hedblad; Pietro Minuz; Marju Orho-Melander; Cristiano Fava; Olle Melander
• Avdelning/ar: Diabetes - kardiovaskulär sjukdom; Translationell Muskel Forskning; Internmedicin - epidemiologi; Kardiovaskulär forskning - epidemiologi; Kardiovaskulär forskning - hypertoni; EXODIAB: Excellence of Diabetes Research in Sweden; EpiHealth: Epidemiology for Health
• Publiceringsår: 2015
• Språk: Engelska
• Sidor: 126-133
• Publikation/Tidskrift/Serie: Prostaglandins & other Lipid Mediators
• Volym: 120
• Issue: May 16
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/25986600?dopt=Abstract; http://dx.doi.org/10.1016/j.prostaglandins.2015.05.003
• Dokumenttyp: Artikel i tidskrift
• Förlag: Elsevier
• Ämne: Endocrinology and Diabetes; Cardiac and Cardiovascular Systems
• Status: Published
• Forskningsgrupp: Diabetes - Cardiovascular Disease; Genomics, Diabetes and Endocrinology; Internal Medicine - Epidemiology; Cardiovascular Research - Epidemiology; Cardiovascular Research - Hypertension
• ISBN/ISSN/Övrigt: ISSN: 1098-8823