Effects of arsenic trioxide and hypoxia in multidrug-resistant neuroblastoma
Författare
Summary, in English
In order to mimic growth conditions in a solid tumour, neuroblastoma cells were grown at hypoxia in presence or absence of glucose. Growth in absence of glucose induced cell death at normoxia conditions, but growth at hypoxic conditions could inhibit the glucose-deficiency induced cell death. Hypoxic growth conditions seem to rescue the cells through inhibiting glucose-deficiency induced activation of caspases and through induced expression of survival-promoting factors signalling through the MAPK-pathway.
Avdelning/ar
Publiceringsår
2005
Språk
Engelska
Publikation/Tidskrift/Serie
Lund University Faculty of Medicine Doctoral Dissertation Series
Dokumenttyp
Doktorsavhandling
Förlag
Lund University: Faculty of Medicine
Ämne
- Cancer and Oncology
Nyckelord
- Klinisk biologi
- Clinical biology
- neuroblastoma
- multidrug resistance
- hypoxia
- glucose-deficiency
- cell death
- Bax
- Apoptosis
- arsenic trioxide
Status
Published
Handledare
ISBN/ISSN/Övrigt
- ISSN: 1652-8220
- ISBN: 91-85439-54-1
Försvarsdatum
3 juni 2005
Försvarstid
09:15
Försvarsplats
Main lecture hall, Pathology building, Malmö university hospital
Opponent
- Maria Shoshan (Associate Professor)