Interaction of Bacteroides fragilis and Bacteroides thetaiotaomicron with the kallikrein-kinin system
Författare
Summary, in English
Many bacterial pathogens interfere with the contact system (kallikrein kinin system) in human plasma. Activation of this system has two consequences: cleavage of high-molecular-mass kininogen (HK) resulting in release of the potent proinflammatory peptide bradykinin, and initiation of the intrinsic pathway of coagulation. In this study, two species of the Gram-negative anaerobic commensal organism Bacteroides, namely Bacteroides fragilis and Bacteroides thetaiotaomicron, were found to bind HK and fibrinogen, the major clotting protein, from human plasma as shown by immunoelectron microscopy and Western blot analysis. In addition, these Bacteroides species were capable of activating the contact system at its surface leading to a significant prolongation of the intrinsic coagulation time and also to the release of bradykinin. Members of the genus Bacteroides have been known to act as opportunistic pathogens outside the gut, with B. fragilis being the most common isolate from clinical infections, such as intra-abdominal abscesses and bacteraemia. The present results thus provide more insight into how Bacteroides species cause infection.
Avdelning/ar
Publiceringsår
2011
Språk
Engelska
Sidor
2094-2105
Publikation/Tidskrift/Serie
Microbiology
Volym
157
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
MAIK Nauka/Interperiodica
Ämne
- Infectious Medicine
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1465-2080