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PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor.

Författare:
  • X. Li
  • A. Pontén
  • K. Aase
  • L. Karlsson
  • A. Abramsson
  • M. Uutela
  • G. Bäckström
  • M. Hellström
  • Hans Ehrencrona
  • H. Li
  • P. Soriano
  • C. Betsholtz
  • C. H. Heldin
  • K. Alitalo
  • A. Ostman
  • U. Eriksson
Publiceringsår: 2000
Språk: Engelska
Sidor: 302-309
Publikation/Tidskrift/Serie: Nature Cell Biology
Volym: 2
Nummer: 5
Dokumenttyp: Artikel i tidskrift
Förlag: Nature Publishing Group

Sammanfattning

Platelet-derived growth factors (PDGFs) are important in many types of mesenchymal cell. Here we identify a new PDGF, PDGF-C, which binds to and activates the PDGF alpha-receptor. PDGF-C is activated by proteolysis and induces proliferation of fibroblasts when overexpressed in transgenic mice. In situ hybridization analysis in the murine embryonic kidney shows preferential expression of PDGF-C messenger RNA in the metanephric mesenchyme during epithelial conversion. Analysis of kidneys lacking the PDGF alpha-receptor shows selective loss of mesenchymal cells adjacent to sites of expression of PDGF-C mRNA; this is not found in kidneys from animals lacking PDGF-A or both PDGF-A and PDGF-B, indicating that PDGF-C may have a unique function.

Nyckelord

  • Cell and Molecular Biology
  • Platelet-Derived Growth Factor
  • Myocardium
  • Molecular Sequence Data
  • Mice
  • Mesoderm
  • Lymphokines
  • Ligands
  • Kidney
  • Insects
  • In Situ Hybridization
  • Humans
  • Developmental
  • Gene Expression Regulation
  • Gene Expression
  • Epithelial Cells
  • Endopeptidases
  • Animals
  • COS Cells
  • Protein Structure
  • Tertiary
  • RNA
  • Messenger
  • Rabbits
  • Receptor
  • Platelet-Derived Growth Factor alpha
  • Sequence Homology
  • Amino Acid
  • Transgenes

Övriga

Published
  • ISSN: 1465-7392

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