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Healthy Satiety Effects of Paleolithic diet on Satiety and Risk factors for Cardiovascular disease

Författare:
Publiceringsår: 2007
Språk: Engelska
Sidor: 122
Publikation/Tidskrift/Serie: Faculty of Medicine Doctoral Dissertation Series 2007:145
Dokumenttyp: Doktorsavhandling
Förlag: Division of Family Medicine Department of Clinical Sciences Lund University Sweden
Ytterligare information: T Jönsson, S Olsson, B Ahrén, TC Bøg-Hansen, A Dole and S Lindeberg. 2005. Agrarian diet and diseases of affluence - Do evolutionary novel dietary lectins cause leptin resistance? BMC Endocr Disord, vol 5 T Jönsson, B Ahrén, G Pacini, F Sundler, N Wierup, S Steen, T Sjöberg, M Ugander, J Frostegård, L Göransson and S Lindeberg. 2006. A Paleolithic diet confers higher insulin sensitivity, lower C-reactive protein and lower blood pressure than a cereal-based diet in domestic pigs. Nutr Metab (Lond), vol 3 S Lindeberg, T Jönsson, Y Granfeldt, E Borgstrand, J Soffman, K Sjöström and B Ahrén. 2007. A Paleolithic diet improves glucose tolerance more than a Mediterranean-like diet in individuals with ischemic heart disease. Diabetologia, vol 50 pp 1795-807. T Jönsson, Y Granfeldt, C Erlanson-Albertsson, B Ahrén and S Lindeberg. . A Paleolithic diet is more satiating per calorie than a Mediterranean-like diet in individuals with ischemic heart disease. (submitted)

Sammanfattning

The prevalence of cardiovascular diseases (CVD) exhibits considerable variation across agrarian societies, whereas they are virtually absent in non-agrarian societies such as hunter-gatherer and horticultural societies. When looking for lifestyle factors which could promote CVD, it therefore seems logical to focus on the agrarian lifestyle and ways in which it departs from a non-agrarian lifestyle. The aim of this thesis was to evaluate the effect of a hunter-gatherer diet (also called Paleolithic diet) compared to agrarian diet in prevention of CVD.

In paper I we reviewed evidence from epidemiology and evolutionary biology for a possible maladaptation of human satiety hormone leptin to agrarian diet. We found that leptin resistance hypothetically may be a sign of maladaptation to dietary cereals as staple food, and that lectins could be a cereal constituent with sufficient properties to cause leptin resistance.

In paper II we experimentally studied the long-term effect of a Paleolithic diet compared to a cereal-based diet on risk factors for cardiovascular disease in domestic pigs. We found that a Paleolithic diet conferred higher insulin sensitivity, lower C-reactive protein and lower blood pressure than a cereal-based diet.

In paper III and IV we experimentally studied the effect of a Paleolithic diet compared to a Mediterranean-like diet on risk factors for cardiovascular disease, satiety and leptin in individuals with ischaemic heart disease and either glucose intolerance or type 2 diabetes. Paper III showed that a Paleolithic diet improved glucose tolerance more than a Mediterranean-like diet, and paper IV showed that a Paleolithic diet was more satiating per calorie than a Mediterranean-like diet.

In conclusion, we have found beneficial effects of a Paleolithic diet on risk factors for cardiovascular disease and satiety.

Disputation

2007-11-23
13:00
Föreläsningssal 3, Lund University Hospital, Lund, Sweden
  • Mai-Lis Hellénius (Professor)

Nyckelord

  • Medicine and Health Sciences
  • Cardiovascular system
  • diabetologi
  • sekretion
  • Endokrinologi
  • Cardiovascular Disease
  • Paleolithic Diet
  • Satiety
  • Endocrinology
  • diabetology
  • secreting systems
  • Kardiovaskulära systemet

Övriga

  • Staffan Lindeberg
  • ISSN: 1652-8220
  • ISBN: 978-91-85897-23-0

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