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Conserved function of the Krüppel gap gene in the blowfly Lucilia sericata, despite anterior shift of expression.

Författare

Summary, in English

To determine whether expression patterns of segmentation genes found in Drosophila melanogaster can be scaled to pattern larger insects, we studied the expression of the Krüppel (Kr) gene in the blowfly Lucilia sericata. Compared with Drosophila Kr, L. sericata Kr showed an unexpected 10% shift of expression towards the anterior pole. Furthermore, expression domains not found in D. melanogaster were present at the blastoderm stage of L. sericata. To compare Kr activity and function, we employed RNA interference-mediated gene silencing. We found Kr phenotypes in L. sericata comparable with those observed in D. melanogaster, demonstrating that L. sericata Kr functions as a gap gene as it does in Drosophila. Our results show that, despite an anterior shift in expression, Kr function has remained conserved during the evolution of the blowflies.

Avdelning/ar

  • Invertebrate Developmental Biology, Stefan Baumgartner's group

Publiceringsår

2011

Språk

Engelska

Sidor

257-265

Publikation/Tidskrift/Serie

Insect Molecular Biology

Volym

20

Dokumenttyp

Artikel i tidskrift

Förlag

Wiley-Blackwell

Ämne

  • Developmental Biology

Status

Published

Projekt

  • Formation of the bicoid gradient in Drosophila

Forskningsgrupp

  • Invertebrate Developmental Biology, Stefan Baumgartner's group

ISBN/ISSN/Övrigt

  • ISSN: 1365-2583