Guiding molecular motors with nano-imprinted structures
Författare
Summary, in English
This work, for the first time, demonstrates that nano-imprinted samples, with 100 nm wide polymer lines, can act as guides for molecular motors consisting of motor proteins actin and myosin. The motor protein function was characterized using fluorescence microscopy and compared to actomyosin motility on non-structured nitrocellulose surfaces. Our results open for further use of the nano-imprint technique in the production of disposable chips for bio-nanotechnological applications and miniaturized biological test systems. We discuss how the nano-imprinted motor protein assay system may be optimized and also how it compares to previously tested assay systems involving low-resolution UV-lithography and low throughput but high-resolution electron beam lithography.
Avdelning/ar
Publiceringsår
2005
Språk
Engelska
Sidor
3337-3340
Publikation/Tidskrift/Serie
Japanese Journal of Applied Physics
Volym
44
Issue
5A
Dokumenttyp
Artikel i tidskrift
Förlag
IOP Publishing
Ämne
- Condensed Matter Physics
Nyckelord
- lab-on-a-chip
- myosin
- actin
- molecular motors
- nano-imprinting
- factory-on-a-chip
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 0021-4922