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Investigation of the fetal heart circulation in an animal model using contrast enhanced ultrasound

Publiceringsår: 2005
Språk: Engelska
Sidor: 125-126
Publikation/Tidskrift/Serie: Proceedings of the International Federation for Medical & Biomedical Engineering. 13th Nordic Baltic Conference on Biomedical Engineering and Medical Physics
Dokumenttyp: Konferensbidrag
Förlag: Int. Federation for Medical and Biological Eng

Sammanfattning

To assess the distribution of blood from the umbilical vein (UMV), inferior vena cava (IVC) and superior vena cava (SVC) to either side of the fetal lamb heart by using ultrasound enhanced contrast agent imaging. By injection of ultrasound contrast agents (UCA) in UMV, IVC or SVC, the blood from these vessels was tracked, as it then was highly echogenic. By evaluating the image intensity within the heart ventricles, the relative concentrations of blood could be determined. The study was performed in 19 near term fetal lambs of mixed breed, with a mean gestational age of 136 days (range 134-136). Ultrasound contrast agent was injected at a constant rate of 1 ml/min, to ensure that a constant level of contrast agent would be obtained in both sides of the heart. Results: the median percentages of blood distributed to the left ventricle when injecting contrast in UMV, IVC, and SVC, was 68%, 67%, and 21% respectively. These numbers compare well with previously published data, except the recorded percentage distributed from the IVC. This could be a methodological error as well as a result of the mild hypoxia, or an actual increased capacity of the left ventricle at this gestational age

Disputation

Nyckelord

  • Medicine and Health Sciences
  • image intensity
  • blood vessel
  • ultrasound contrast agent
  • fetal lamb heart
  • superior vena cava
  • inferior vena cava
  • umbilical vein
  • blood distribution
  • contrast enhanced ultrasound
  • fetal heart circulation investigation
  • animal model
  • heart ventricle
  • blood concentration
  • gestation
  • hypoxia

Övriga

Proceedings of the International Federation for Medical & Biomedical Engineering. 13th Nordic Baltic Conference on Biomedical Engineering and Medical Physics
13-17 June 2005
Umea, Sweden
Published
Yes
  • ISBN: 91-7305-910-2

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