Antiproliferative effects of peracetylated naphthoxylosides.

Summary, in English

The antiproliferative activity, and the capability of priming of glycosaminoglycan chains, of two series of peracetylated mono- and bis-xylosylated dihydroxynaphthalenes have been investigated for normal HFL-1 cells, as well as transformed T24 cells, and compared to the unprotected analogs. Our data show increased antiproliferative activity upon peracetylation, but a loss of selectivity towards T24 cells.

• Författare: Ulrika Aili; Mårten Jacobsson; Richard Johnsson; Katrin Mani; Ulf Ellervik
• Avdelning/ar: Glykobiologigruppen; Centrum för analys och syntes
• Publiceringsår: 2009
• Språk: Engelska
• Sidor: 1763-1766
• Publikation/Tidskrift/Serie: Bioorganic & Medicinal Chemistry Letters
• Volym: 19
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/19217282?dopt=Abstract; http://dx.doi.org/10.1016/j.bmcl.2009.01.065
• Dokumenttyp: Artikel i tidskrift
• Förlag: Elsevier
• Ämne: Medicinal Chemistry
• Status: Published
• Forskningsgrupp: Glycobiology
• ISBN/ISSN/Övrigt: ISSN: 0960-894X