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C-Kit signal transduction and involvement in cancer

Författare

  • Johan Lennartsson
  • Olexandr Voytyuk
  • Elke Heiss
  • Christina Sundberg
  • Jianmin Sun
  • Lars Rönnstrand

Summary, in English

Receptor tyrosine kinases, such as c-Kit, are proteins whose function it is to transduce signals from the environment into the cell leading to complex behaviors such as proliferation, migration, survival and differentiation. Many of these behaviors are deregulated in cancer, which is characterized by uncontrolled proliferation, insensitivity

towards death stimuli, migration of tumor cells away from the primary tumor site and in some cases also block of

cellular differentiation leaving the cell in an immature proliferative state. To be able to target these processes it is vital to have a detailed understanding of the receptor function and the downstream pathways activated. In this article we will review the mechanisms by which c-Kit induces signal transduction as well as describing tumors in

which c-Kit function is perturbed.

Publiceringsår

2005

Språk

Engelska

Sidor

5-28

Publikation/Tidskrift/Serie

Cancer Therapy

Volym

3

Dokumenttyp

Artikel i tidskrift

Förlag

International Society of Cancer Therapy

Ämne

  • Medicinal Chemistry

Nyckelord

  • Fertility
  • Phospholipase C-g
  • PI3-kinase
  • Ras/Erk pathway
  • degradation
  • Transcription factors
  • Adapter proteins
  • tyrosine kinases
  • c-Kit signal transduction
  • Dimerization
  • Internalization
  • cancer
  • Protein tyrosine phosphatases
  • Hematopoiesis
  • Gastrointestinal tract
  • Nervous system
  • Mastocytosis
  • Melanoma
  • Small-cell lung cancer
  • JAK/STAT pathway
  • homeostasis
  • Pigmentation

Status

Published