Deep sequencing and SNP array analyses of pediatric T-cell acute lymphoblastic leukemia reveal NOTCH1 mutations in minor subclones and a high incidence of uniparental isodisomies affecting CDKN2A.

Summary, in English

Pediatric T-cell acute lymphoblastic leukemia (T-ALL) is a genetically heterogeneous disease that arises in a multistep fashion through acquisition of several genetic aberrations, subsequently giving rise to a malignant, clonal expansion of T-lymphoblasts. The aim of the present study was to identify additional as well as cooperative genetic events in T-ALL.

• Författare: Kristina Karrman; Anders Castor; Mikael Behrendtz; Erik Forestier; Linda Olsson; Mats Ehinger; Andrea Biloglav; Thoas Fioretos; Kajsa Paulsson; Bertil Johansson
• Avdelning/ar: Genetiska och epigenetiska studier av barnleukemi; Avdelningen för klinisk genetik; Pediatrik, Lund; Tumörmikromiljö; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
• Publiceringsår: 2015
• Språk: Engelska
• Publikation/Tidskrift/Serie: Journal of Hematology & Oncology
• Volym: 8
• Issue: 1
• Fulltext: - 764 kB; Download statistics
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/25903014?dopt=Abstract; http://dx.doi.org/10.1186/s13045-015-0138-0
• Dokumenttyp: Artikel i tidskrift
• Förlag: BioMed Central (BMC)
• Ämne: Medical Genetics; Pediatrics; Cancer and Oncology
• Status: Published
• Forskningsgrupp: Genetic and epigenetic studies of pediatric leukemia
• ISBN/ISSN/Övrigt: ISSN: 1756-8722