Coevolution of the domains of cytoplasmic tyrosine kinases
Författare
Summary, in English
Many signaling molecules are multidomain proteins that have other domains in addition to the catalytic kinase domain. Protein tyrosine kinases almost without exception contain Src homology 2 (SH2) and/or SH3 domains that can interact with other signaling proteins. Here, we studied evolution of the tyrosine kinases containing SH2 and/or SH3 and kinase domains. The three domains seem to have duplicated together, since the phylogenetic analysis using parsimony gave almost identical evolutionary trees for the separate domains and the multidomain complexes. The congruence analysis of the sequences for the separate domains also suggested that the domains have coevolved. There are several reasons for the domains to appear in a cluster. Kinases are regulated in many ways, and the presence of SH2 and SH3 domains at proper positions is crucial. Because all three domains can recognize different parts of ligands and substrates, their evolution has been interconnected. The reasons for the clustering and coevolution of the three domains in protein tyrosine kinases (PTKs) are discussed.
Publiceringsår
2001
Språk
Engelska
Sidor
312-321
Publikation/Tidskrift/Serie
Molecular biology and evolution
Volym
18
Issue
3
Dokumenttyp
Artikel i tidskrift
Förlag
Oxford University Press
Ämne
- Medical Genetics
Nyckelord
- evolution
- phylogenetics
- SH2
- SH3
- protein kinase
- tyrosine kinase
- structural conservation
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 0737-4038