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Active and passive immunization for atherosclerosis

In English

Författare

Summary, in English

This review summarizes experimental findings that highlight the role of immune mechanisms in atherosclerosis and the potential atheroprotective effects of active or passive immunization strategies. Immunomodulation therapy appears to be feasible and effective, suggesting that a vaccine for atherosclerosis can be developed for clinical testing. Given the increasing number of patients with atherosclerotic disease on current therapy, a new therapy is needed and an immunization strategy could provide such a possibility. Several questions regarding this approach remain unanswered, however, such as choice of optimal antigens, choice of most effective adjuvants, the optimal route of administration, durability of effects and safety, but cautious optimism remains that a vaccine-based approach has the potential to become a part of the armamentarium for atherosclerotic vascular disease.

Publiceringsår

2007

Språk

Engelska

Sidor

176-182

Publikation/Tidskrift/Serie

Current Opinion in Molecular Therapeutics

Volym

9

Issue

2

Dokumenttyp

Artikel i tidskrift

Förlag

Thomson Reuters

Ämne

  • Cardiac and Cardiovascular Systems

Nyckelord

  • immunization
  • atherosclerosis
  • immune response
  • vaccination

Status

Published

Forskningsgrupp

  • Cardiovascular Research - Immunity and Atherosclerosis

ISBN/ISSN/Övrigt

  • ISSN: 2040-3445