Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates
Författare
Summary, in English
Huntington's disease (HD) causes widespread CNS changes and systemic abnormalities including endocrine and immune dysfunction. HD biomarkers are needed to power clinical trials of potential treatments. We used multiplatform proteomic profiling to reveal plasma changes with HD progression. Proteins of interest were evaluated using immunoblotting and ELISA in plasma from 2 populations, CSF and R6/2 mice. The identified proteins demonstrate neuroinflammation in HD and warrant further investigation as possible biomarkers.
Avdelning/ar
Publiceringsår
2007
Språk
Engelska
Sidor
2833-2840
Publikation/Tidskrift/Serie
Journal of Proteome Research
Volym
6
Issue
7
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
The American Chemical Society (ACS)
Ämne
- Basic Medicine
Nyckelord
- electrophoresis
- 2D
- proteomics
- neuroinflammation
- Huntington's disease
- plasma
- LC/MS/MS
- MALDI-TOF
- ELISA
- biomarkers
Status
Published
Forskningsgrupp
- Translational Neuroendocrinology
ISBN/ISSN/Övrigt
- ISSN: 1535-3893